Social Work profession has been committed to the defense and promotion of Human Rights. Social workers focus on working with the most vulnerable populations across the world regardless of ethnicity, language, gender, ideology, age, physical ability, status or any other condition liable to lead to discrimination. Social work pioneers such as Jane Addams, Grace and Edith Abbott, have left a legacy of dedicated and committed work with new immigrants. Settlement houses, neighborhood centers. In recent years social work face a challenge how to continue in its role with refugees and asylum seekers. This paper discuss who refugee, what international organizations support and work with them, social work role with refugees, and challenges for Social Work Practice with them.